微信公众号

官网二维码

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (2): 163-166.doi: 10.3969/j.issn.1674-5671.2012.02.16

• 肝癌专栏 • 上一篇    下一篇

 283例原发性肝癌三维适形放疗的预后因素分析

  

  1. 广西医科大学附属肿瘤医院放疗科;广西医科大学研究生学院
  • 出版日期:2012-06-25 发布日期:2012-07-03
  • 通讯作者: 梁世雄 E-mail:shixliang@vip.sina.com
  • 基金资助:

    广西卫生厅重点科研课题(重2010071)

Prognostic factors when using three-dimensional conformal radiotherapy to treat primary liver cancer: an analysis of 283 cases

  • Online:2012-06-25 Published:2012-07-03

摘要: 目的 评价三维适形放射治疗(3DCRT)对原发性肝癌的疗效,探讨其预后影响因素。方法 对283例原发性肝癌患者进行3DCRT,肿瘤剂量(51.85±6.55)Gy,每次分割剂量(4.55±1.02)Gy,照射次数(10±4)次,每周3次,隔日1次。结果 原发性肝癌3DCRT总有效率(CR+PR)为47.35%(134/283),1、3、5年总生存率分别为57.0%、29.0%和18.0%,性别、CLIP分期、GTV、PVTT和Child-Pugh分级对预后影响的差异有统计学意义(P均<0.01),性别、GTV、PVTT和Child-Pugh分级是独立的预后因素(P=0.008、0.007、0.006和0.003)。结论 性别、GTV、PVTT和Child-Pugh分级是影响原发性肝癌3DCRT独立的预后因素。

关键词: 肝肿瘤, 三维适形放射治疗, 预后

Abstract: Objective To evaluate the efficacy of three-dimensional conformal radiotherapy(3DCRT)to treat primary liver cancer (PLC)and investigate the prognostic factors associated with its use. Methods PLC patients(n = 283)were treated with 3DCRT using a total dose of 51.85±6.55 Gy(4.55±1.02 Gy/fraction,3 fractions/week,10±4 total fractions). Results The response rate(CR+PR)was 47.35%(134/283).The 1-,3-,and 5-year overall survival rates were 57.0%,29.0% and 18.0%,respectively.Gender,CLIP stage,GTV,PVTT and Child-Pugh class were found to significantly affect overall survival(P<0.01).Independent prognostic factors were gender(P=0.008),GTV(P=0.007),PVTT(P=0.006)and Child-Pugh class(P=0.003).Conclusion Gender,GTV,PVTT and Child-Pugh class may be independent prognostic factors when using 3DCRT to treat PLC.

Key words: Liver neoplasms, Three-dimensional conformal radiotherapy, Prognosis